Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk
Identifieur interne : 005436 ( Main/Exploration ); précédent : 005435; suivant : 005437Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk
Auteurs : Celine M. Vachon ; Christopher G. Scott ; Peter A. Fasching ; Per Hall ; Rulla M. Tamimi ; Jingmei Li ; Jennifer Stone ; Carmel Apicella ; Fabrice Odefrey ; Gretchen L. Gierach ; Sebastian M. Jud ; Katharina Heusinger ; Matthias W. Beckmann ; Marina Pollan ; Pablo Fernández-Navarro ; Anna González-Neira ; Javier Benítez ; Carla H. Van Gils ; Mariëtte Lokate ; N. Charlotte Onland-Moret ; Petra H. M. Peeters ; Judith Brown ; Jean Leyland ; Jajini S. Varghese ; Douglas F. Easton ; Deborah J. Thompson ; Robert N. Luben ; Ruth Ml Warren ; Nicholas J. Wareham ; Ruth Jf Loos ; Kay-Tee Khaw ; Giske Ursin ; Eunjung Lee ; Simon A. Gayther ; Susan J. Ramus ; Rosalind A. Eeles ; Martin O. Leach ; Gek Kwan-Lim ; Fergus J. Couch ; Graham G. Giles ; Laura Baglietto ; Kavitha Krishnan ; Melissa C. Southey ; Loic Le Marchand ; Laurence N. Kolonel ; Christy Woolcott ; Gertraud Maskarinec ; Christopher A. Haiman ; Kate Walker ; Nichola Johnson ; Valerie A. Mccormack ; Margarethe Biong ; Grethe I. G. Aln S ; Inger Torhild Gram ; Vessela N. Kristensen ; Anne-Lise B Rresen-Dale ; Sara Lindström ; Susan E. Hankinson ; David J. Hunter ; Irene L. Andrulis ; Julia A. Knight ; Norman F. Boyd ; Jonine D. Figueroa ; Jolanta Lissowska ; Ewa Wesolowska ; Beata Peplonska ; Agnieszka Bukowska ; Edyta Reszka ; Jianjun Liu ; Louise Eriksson ; Kamila Czene ; Tina Audley ; Anna H. Wu ; V. Shane Pankratz ; John L. Hopper ; Isabel Dos-Santos-SilvaSource :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2012.
Abstract
Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biological mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to inter-individual differences in mammographic density measures.
We established an international consortium (DENSNP) of 19 studies from 10 countries, comprising 16,895 Caucasian women, to conduct a pooled cross-sectional analysis of common breast cancer susceptibility variants in 14 independent loci and mammographic density measures. Dense and non-dense areas, and percent density, were measured using interactive-thresholding techniques. Mixed linear models were used to assess the association between genetic variants and the square roots of mammographic density measures adjusted for study, age, case status, body mass index (BMI) and menopausal status.
Consistent with their breast cancer associations, the C-allele of rs3817198 in
We identified two common breast cancer susceptibility variants associated with mammographic measures of radio-dense tissue in the breast gland.
We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants,
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DOI: 10.1158/1055-9965.EPI-12-0066
PubMed: 22454379
PubMed Central: 3569092
Affiliations:
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Wu</name></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22454379</idno><idno type="pmc">3569092</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569092</idno><idno type="RBID">PMC:3569092</idno><idno type="doi">10.1158/1055-9965.EPI-12-0066</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002088</idno><idno type="wicri:Area/Pmc/Curation">001F42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F42</idno><idno type="wicri:Area/Pmc/Checkpoint">002015</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002015</idno><idno type="wicri:Area/Ncbi/Merge">000D57</idno><idno type="wicri:Area/Ncbi/Curation">000D57</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D57</idno><idno type="wicri:doubleKey">1055-9965:2012:Vachon C:common:breast:cancer</idno><idno type="wicri:Area/Main/Merge">005692</idno><idno type="wicri:Area/Main/Curation">005436</idno><idno type="wicri:Area/Main/Exploration">005436</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Breast Cancer Susceptibility Variants in <italic>LSP1</italic> and <italic>RAD51L1</italic> Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk</title><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name></author><author><name sortKey="Scott, Christopher G" sort="Scott, Christopher G" uniqKey="Scott C" first="Christopher G." last="Scott">Christopher G. Scott</name></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M." last="Tamimi">Rulla M. Tamimi</name></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name></author><author><name sortKey="Gierach, Gretchen L" sort="Gierach, Gretchen L" uniqKey="Gierach G" first="Gretchen L." last="Gierach">Gretchen L. Gierach</name></author><author><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M." last="Jud">Sebastian M. Jud</name></author><author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name></author><author><name sortKey="Pollan, Marina" sort="Pollan, Marina" uniqKey="Pollan M" first="Marina" last="Pollan">Marina Pollan</name></author><author><name sortKey="Fernandez Navarro, Pablo" sort="Fernandez Navarro, Pablo" uniqKey="Fernandez Navarro P" first="Pablo" last="Fernández-Navarro">Pablo Fernández-Navarro</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H." last="Van Gils">Carla H. Van Gils</name></author><author><name sortKey="Lokate, Mariette" sort="Lokate, Mariette" uniqKey="Lokate M" first="Mariëtte" last="Lokate">Mariëtte Lokate</name></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H. M." last="Peeters">Petra H. M. Peeters</name></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name></author><author><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name></author><author><name sortKey="Varghese, Jajini S" sort="Varghese, Jajini S" uniqKey="Varghese J" first="Jajini S." last="Varghese">Jajini S. Varghese</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name></author><author><name sortKey="Warren, Ruth Ml" sort="Warren, Ruth Ml" uniqKey="Warren R" first="Ruth Ml" last="Warren">Ruth Ml Warren</name></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name></author><author><name sortKey="Loos, Ruth Jf" sort="Loos, Ruth Jf" uniqKey="Loos R" first="Ruth Jf" last="Loos">Ruth Jf Loos</name></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name></author><author><name sortKey="Leach, Martin O" sort="Leach, Martin O" uniqKey="Leach M" first="Martin O." last="Leach">Martin O. Leach</name></author><author><name sortKey="Kwan Lim, Gek" sort="Kwan Lim, Gek" uniqKey="Kwan Lim G" first="Gek" last="Kwan-Lim">Gek Kwan-Lim</name></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name></author><author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Walker, Kate" sort="Walker, Kate" uniqKey="Walker K" first="Kate" last="Walker">Kate Walker</name></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></author><author><name sortKey="Mccormack, Valerie A" sort="Mccormack, Valerie A" uniqKey="Mccormack V" first="Valerie A." last="Mccormack">Valerie A. Mccormack</name></author><author><name sortKey="Biong, Margarethe" sort="Biong, Margarethe" uniqKey="Biong M" first="Margarethe" last="Biong">Margarethe Biong</name></author><author><name sortKey="Aln S, Grethe I G" sort="Aln S, Grethe I G" uniqKey="Aln S G" first="Grethe I. G." last="Aln S">Grethe I. G. Aln S</name></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Boyd, Norman F" sort="Boyd, Norman F" uniqKey="Boyd N" first="Norman F." last="Boyd">Norman F. Boyd</name></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name></author><author><name sortKey="Wesolowska, Ewa" sort="Wesolowska, Ewa" uniqKey="Wesolowska E" first="Ewa" last="Wesolowska">Ewa Wesolowska</name></author><author><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name></author><author><name sortKey="Bukowska, Agnieszka" sort="Bukowska, Agnieszka" uniqKey="Bukowska A" first="Agnieszka" last="Bukowska">Agnieszka Bukowska</name></author><author><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name></author><author><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name></author><author><name sortKey="Audley, Tina" sort="Audley, Tina" uniqKey="Audley T" first="Tina" last="Audley">Tina Audley</name></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biological mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to inter-individual differences in mammographic density measures.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We established an international consortium (DENSNP) of 19 studies from 10 countries, comprising 16,895 Caucasian women, to conduct a pooled cross-sectional analysis of common breast cancer susceptibility variants in 14 independent loci and mammographic density measures. Dense and non-dense areas, and percent density, were measured using interactive-thresholding techniques. Mixed linear models were used to assess the association between genetic variants and the square roots of mammographic density measures adjusted for study, age, case status, body mass index (BMI) and menopausal status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Consistent with their breast cancer associations, the C-allele of rs3817198 in <italic>LSP1</italic> was positively associated with both adjusted dense area (p=0.00005) and adjusted percent density (p=0.001) whereas the A-allele of rs10483813 in <italic>RAD51L1</italic> was inversely associated with adjusted percent density (p=0.003), but not with adjusted dense area (p=0.07).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">We identified two common breast cancer susceptibility variants associated with mammographic measures of radio-dense tissue in the breast gland.</p></sec><sec id="S5"><title>Impact</title><p id="P5">We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants, <italic>LSP1</italic>-rs3817198 and <italic>RAD51L1</italic>-rs10483813, associated with mammographic measures and in the same direction as the breast cancer association.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aln S, Grethe I G" sort="Aln S, Grethe I G" uniqKey="Aln S G" first="Grethe I. G." last="Aln S">Grethe I. G. Aln S</name><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><name sortKey="Audley, Tina" sort="Audley, Tina" uniqKey="Audley T" first="Tina" last="Audley">Tina Audley</name><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><name sortKey="Biong, Margarethe" sort="Biong, Margarethe" uniqKey="Biong M" first="Margarethe" last="Biong">Margarethe Biong</name><name sortKey="Boyd, Norman F" sort="Boyd, Norman F" uniqKey="Boyd N" first="Norman F." last="Boyd">Norman F. Boyd</name><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><name sortKey="Bukowska, Agnieszka" sort="Bukowska, Agnieszka" uniqKey="Bukowska A" first="Agnieszka" last="Bukowska">Agnieszka Bukowska</name><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><name sortKey="Fernandez Navarro, Pablo" sort="Fernandez Navarro, Pablo" uniqKey="Fernandez Navarro P" first="Pablo" last="Fernández-Navarro">Pablo Fernández-Navarro</name><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name><name sortKey="Gierach, Gretchen L" sort="Gierach, Gretchen L" uniqKey="Gierach G" first="Gretchen L." last="Gierach">Gretchen L. Gierach</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M." last="Jud">Sebastian M. Jud</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name><name sortKey="Kwan Lim, Gek" sort="Kwan Lim, Gek" uniqKey="Kwan Lim G" first="Gek" last="Kwan-Lim">Gek Kwan-Lim</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Leach, Martin O" sort="Leach, Martin O" uniqKey="Leach M" first="Martin O." last="Leach">Martin O. Leach</name><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><name sortKey="Lokate, Mariette" sort="Lokate, Mariette" uniqKey="Lokate M" first="Mariëtte" last="Lokate">Mariëtte Lokate</name><name sortKey="Loos, Ruth Jf" sort="Loos, Ruth Jf" uniqKey="Loos R" first="Ruth Jf" last="Loos">Ruth Jf Loos</name><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><name sortKey="Mccormack, Valerie A" sort="Mccormack, Valerie A" uniqKey="Mccormack V" first="Valerie A." last="Mccormack">Valerie A. Mccormack</name><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H. M." last="Peeters">Petra H. M. Peeters</name><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name><name sortKey="Pollan, Marina" sort="Pollan, Marina" uniqKey="Pollan M" first="Marina" last="Pollan">Marina Pollan</name><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name><name sortKey="Scott, Christopher G" sort="Scott, Christopher G" uniqKey="Scott C" first="Christopher G." last="Scott">Christopher G. Scott</name><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M." last="Tamimi">Rulla M. Tamimi</name><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H." last="Van Gils">Carla H. Van Gils</name><name sortKey="Varghese, Jajini S" sort="Varghese, Jajini S" uniqKey="Varghese J" first="Jajini S." last="Varghese">Jajini S. Varghese</name><name sortKey="Walker, Kate" sort="Walker, Kate" uniqKey="Walker K" first="Kate" last="Walker">Kate Walker</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><name sortKey="Warren, Ruth Ml" sort="Warren, Ruth Ml" uniqKey="Warren R" first="Ruth Ml" last="Warren">Ruth Ml Warren</name><name sortKey="Wesolowska, Ewa" sort="Wesolowska, Ewa" uniqKey="Wesolowska E" first="Ewa" last="Wesolowska">Ewa Wesolowska</name><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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